The highest numbers of patients experiencing liver relapse were found in the HER2-positive luminal B group and the luminal B subtype, confirming that increased phosphorylation of HER2 with high Ki-67 positivity appear to be extremely important for the establishment of BC liver metastases and the prediction of visceral recurrence, but this failed to reach statistical significance (p: 0.401) [43]. This evidence concerns the gene MKI67 and breast cancer.