MYC and lymphoma: Similar to germline Tp53+/- heterozygosity, conditional B-lymphoid-specific loss of one allele of p53 caused early-onset MYC-driven lymphomas with a median survival of 37 days (Fig 9B), compared to a median survival of ~120 days for the Mb1-Cre Eμ-Myc control mice on this genetic background [18].