However, treatment with r-tPA is accompanied by a fatal complication known as symptomatic intracranial hemorrhage (sICH), which can worsen the outcomes of stroke patients[2].According to NINDS criteria, the incidence rate of sICH is 2.2% to 8% across the world[3–7], and 4.87% to 7.3% in China[8–9].Ginsberg reported that symptomatic intracranial hemorrhage is fatal in 41.4% of cases [10]. Here, PLAT is linked to intracranial hemorrhage.