In agreement with our findings, Sombat M, et al reported that age>75 years increasesby1.532 times the risk of sICH in Thai AIS patients who accepted iv r-tPA thrombosis[19].However, two studies in Australia[20] and Japan[21] reported that age over 80 years is not related to sICH risk increase. The gene discussed is PLAT; the disease is androgen insensitivity syndrome.