MYCN and neoplasm: MYCN expression status explained most of the remaining gene expression variability in tumor and DTC samples (second principal component, y‐axis) (Fig. 3b), revealing a strong effect of MYCN upregulation on the global gene expression of tumors (n = 6 with MYCN‐low and n = 10 with MYCN‐high) and DTCs (n = 26 with MYCN‐low and n = 16 with MYCN‐high).