Notably, we identified five tumor suppressors among the 31 downregulated genes; STK11, SIRT6, CADM4, BBC3 (also known as PUMA) and GLTSCR2. Genomic analysis of 34 DTC samples revealed clonal deletions affecting a portion of the 31 downregulated genes encoded by chromosome 19. The gene discussed is NOP53; the disease is neoplasm.