NPM1 and acute myeloid leukemia: Conversely, c-Myc is stabilized in cells lacking NPM1 and, importantly, in AML blasts bearing the mutated form of NPM1.21 Indeed, mutations causing NPM1 cytoplasmic delocalization, do not compromise the interaction of NPM1 with Fbw7γ which is also delocalized in the cytoplasm and degraded.21 A similar delocalization/degradation mechanism was observed with the tumor suppressor p14ARF.24, 25 Overall, different apoptotic responses are compromised by the selective cytosolic degradation of NPM1 partners.