NPM1 and acute myeloid leukemia: Based on the experimental observations we outlined above, we have recently suggested that an effective strategy to specifically target AML with NPM1 mutations would be that of interfering with NPM1 protein–protein interactions.16 Here, we have characterized the extended surface of Nter-NPM1 involved in protein binding and thus provided a structural framework to search for small molecules and/or peptidomimetics targeting this surface.