TMIGD2 and cancer: Tumor cells often coopt to cellular aggregation by interacting with each other or other cell types to lessen the cytotoxic effects of chemotherapeutics, a phenomenon known as ‘multicellular resistance’.39 Multicellular resistance occurs in response to a variety of anti-cancer strategies, including chemotherapy and ionizing radiation.12, 40 Considering the effects of IGPR-1 on tumor multicellular aggregation, we examined whether IGPR-1expression in tumor cells influences the chemosensitivity of colon tumor cells to doxorubicin.