Despite the relatively low levels of IGPR-1 expression in HCT116 cells, depletion of IGPR-1 by shRNA markedly decreased survival of HCT116 cells in suspension (Figures 4a and b), and tumor growth in mouse (Figure 4c), underscoring the biological importance of IGPR-1 for tumor cell survival. Here, TMIGD2 is linked to neoplasm.