Similarly, 1A12 antibody (10 μg weekly injection) inhibited the growth of HCT116 cells expressing IGPR-1 by only 36% (average tumor volume for mice receiving control IgG was 390 mm3±33 vs mice receiving 1A12 IgG was 251 mm3± 39; Figure 4e). Here, TMIGD2 is linked to neoplasm.