The acquisition of apoptotic resistance by tumor cells is one of the hallmarks of cancer,62 and, in many cases, the loss of functional p53 and expression of certain classes of CAMs help tumor cells to avoid cell death and survive.63, 64, 65, 66 In this regard, it is possible that increased IGPR-1 expression in tumor cells provides a distinct survival mechanism for these cells. This evidence concerns the gene TMIGD2 and neoplasm.