To investigate the potential role of IGPR-1 in human colorectal cancer (CRC), we examined expression of IGPR-1 in CRC by staining CRC biopsies of patients treated at Boston University School of Medicine using a pre-validated IGPR-1 antibody.29, 30 The cohort consisted of 29 human colorectal cancer specimens (19 cases of well or moderately differentiated CRC, 3 cases of poorly or undifferentiated CRC, and 7 cases of mucinous CRC), and 6 patients with non-neoplastic tubular adenoma were compared to 12 patients in whom normal colonic tissue was adjacent to CRC. This evidence concerns the gene TMIGD2 and colorectal carcinoma.