Loss of cell adhesion to ECM triggers activation of stress-induced pro-apoptotic p38 MAPK.34, 35 Since IGPR-1 expression in HCT116 and HT29 cells promoted tumor cell survival in the absence of adhesion to ECM, we hypothesized that the ability of IGPR-1 to promote survival of tumor cells in tumorsphere conditions is mediated by inhibition of p38. Here, TMIGD2 is linked to neoplasm.