1A12 antibody (10 μg/ml) reduced the survival of HCT116 cells by 48%, whereas at the same concentration of 1A12 antibody inhibited the survival of IGPR-1/HCT116 cells by 26% (Supplementary Figure 5A compared to 5C), indicating that overexpression of IGPR-1 in HCT116 cells increased tumor growth, which requires more blocking 1A12 antibody to reduce its pro-growth function. Here, TMIGD2 is linked to neoplasm.