RB1 and cancer: Moreover, viral proteins like HPV E7 and SV40 large T antigen support transformation of cells and cancer development (McLaughlin-Drubin and Münger, 2009) and disrupt DREAM (Fischer et al., 2017; Nor Rashid et al., 2011; Pang et al., 2014) as well as E2f/Rb complexes (Dyson et al., 1989).