INS and Hypoglycemia: A study of adults with DM2 using a German/Austrian database also illustrated this, showing that in those using insulin or sulfonylureas, the rates of severe hypoglycemia, defined as requiring assistance from others to remedy, (14.8 ± 0.6 versus 10.4 ± 0.2 events per 100 patient-years, p < 0.001) and hypoglycemia with coma (7.6 ± 0.4 versus 3.9 ± 0.1 events per 100 patient-years, p < 0.001) were significantly higher in patients with dementia, much of which was vascular dementia in that study [71].