E7046 + E7777 treatment activated the innate immune system which led to an “inflamed” TME evidenced by expression of genes encoding Ccl5/RANTES, macrophage inflammatory protein-1α (MIP-1α/Ccl3), Cxcl9, Cxcl10, and Cxcl11, previously found associated with tumor destruction.41 This evidence concerns the gene CCL5 and neoplasm.