MTOR and early-onset autosomal dominant Alzheimer disease: This could be particularly relevant for effects of rapamycin on cognitive aging and dementia, as numerous studies have shown that rapamycin and mTOR inhibition can delay cognitive decline during normative aging (Halloran et al., 2012; Majumder et al., 2012) as well as prevent or reverse Alzheimer's disease progression (Spilman et al., 2010; Majumder et al., 2011; Lin et al., 2013, 2017; Ozcelik et al., 2013; Caccamo et al., 2014; Jiang et al., 2014; Siman et al., 2015) in mouse models.