A significant up-regulation in APS-1 and controls was found in the analyzed γ-chemokines CCL2, CCL3, and CCL4, the α-chemokine CXCL8, and the interleukins IL-1β, IL-4, IL-6, IL-7, IL-10, IL-12p40, and IL-18 (Table 2). The gene discussed is IL4; the disease is autoimmune polyendocrine syndrome type 1.