Specifically, Aucher and collaborators (145) reported that miR-142 and miR-223, which are endogenously expressed in human macrophages (MØs) but not in hepatocarcinoma cells (HCCs), were transferred from MØs to HCC cells via GJs and effectively target the expression of stathmin-1 and insulin-like growth factor-1 receptor in the acceptor tumor cells leading to the inhibition of tumor cell proliferation. This evidence concerns the gene IGF1R and neoplasm.