Another study indicates that Cx43-GJ-mediated transfer of the antitumoral miRNA miR-145-5p from human microvascular endothelial cells transfected with miR-145-5p mimics to primary colon cancer cells inhibits the cancer-induced tubulogenesis, suggesting that this heterotypic GJIC downregulate colon cancer cell growth by preventing the formation of new vessels (166). This evidence concerns the gene GJA1 and cancer.