RIPK3 and cryptococcosis: Thus, RIPK3 and FADD are not directly involved in regulation lytic cell death of BMDM population infected with C. neoformans in vitro, further supporting that the susceptibility of Ripk3−/− mice and Ripk3−/−Fadd−/− mice to cryptococcal infection was mechanistically unrelated to the role RIPK3 and FADD in necroptosis pathway.