Of particular note is the finding that exercise was previously shown to exert cardioprotective effects in MI mice by inhibiting oxidative stress, ameliorating inflammatory injury, increasing the expression of VEGF (vascular endothelial growth factor) and reducing MI size (Ding et al., 2005; Wu et al., 2009; Salimeh et al., 2013). The gene discussed is VEGFA; the disease is myocardial infarction.