13 (65%) were female, 12 (60%) received tPA, 11 (55%) had atrial fibrillation, 4 (20%) had significant proximal vessel atherosclerosis, 2 (10%) were cryptogenic, and 3 had other identified significant stroke risk factors (left ventricular thrombus, dissection, endocarditis). The gene discussed is PLAT; the disease is thrombotic disease.