LEP and Sepsis: High circulating levels of leptin predicted a first-ever sepsis event (OR 2.04, 95% CI 1.30–3.2, P = 0.002) and retained predictive value after adjustment for BMI (OR 1.89, 95% CI 1.14–3.13, P = 0.01) and in the fully adjusted model (OR 1.77, 95% CI 1.04–3.00, P = 0.03) (Fig. 2).