uPA has been studied in human medicine in several sample types, including serum levels in patients with head and neck squamous cell carcinoma [29], breast cancer [30], ovarian cancer [31] and prostatic cancer [32], and their results suggest that uPA plays important roles in cancer evolution, particularly in processes such as angiogenesis and metastasis and might also be of prognostic and predictive value. Here, PLAU is linked to Familial prostate cancer.