Specifically, the mean expression of EZH2 (1.62 fold decreased, SD 0.36) and GSK3 (1.60 fold decreased, SD 0.35) were reduced in all 5 AML-derived samples compared with controls and the mean expression of KRBA2 (2.34 fold increased, SD 0.75), RRBP1 (3.16 fold increased, SD 1.39), HIST2H2BE (3.04 fold increased, SD 0.90) were all increased (see supplemental Fig. 2). This evidence concerns the gene RRBP1 and acute myeloid leukemia.