Single-nucleotide polymorphisms in ADAM33 have been linked to asthma and bronchial hyperresponsiveness.4, 5ADAM33 encodes a membrane-anchored metalloprotease, but a soluble metalloprotease-containing form of ADAM33 (sADAM33) is increased in bronchoalveolar lavage fluid of asthmatic patients.6, 7 Furthermore, in human embryonic lung explant culture, treatment with sADAM33 induces angiogenesis8 and myogenesis,7 pathological features of airway remodeling in asthma. This evidence concerns the gene ADAM33 and asthma.