Moreover, among a large set of tested proteins, Inverse Virtual Screening in silico approach suggested for the first time a direct interaction of SR141716 with p300/KAT3B, that was corroborated by results from SPR-assay highlighting a direct binding of the compound to the p300-HAT catalytic domain and the significant modulation of acetyl-Histone H3 and acetyl-Histone H4 found in CRC cell lines. Here, EP300 is linked to colorectal carcinoma.