Moreover, SR141716 was able to significantly reduce protein levels of some well known Wnt/β-Catenin target genes, such as Cyclin D1, c-Myc (Avian myelocytomatosis virus oncogene cellular homolog) and COX-2 (Cyclooxygenase-2), involved in CRC progression (Fig. 5b and c and see Supplementary Fig. S5). The gene discussed is PTGS2; the disease is colorectal carcinoma.