In tissue specimens from xenografts, the increased expression of p-β-Catenin and down-regulation of c-Myc and Cyclin D1 represent an encouraging validation of the Rimonabant efficacy in vivo in tumors harboring β-Catenin mutation and provide enough direct evidence for the inhibition of the canonical Wnt/β-Catenin pathway and of β-Catenin target genes by cannabinoid compounds in human CRC. Here, MYC is linked to colorectal carcinoma.