The no-asthma group showed stronger negative association between lung function and insulin resistance than total population (r coefficient for FVC% predicted = −0.138 for insulin level and −0.128 for HOMA-IR, P < 0.0001 for both, r coefficient for FEV1% predicted = −0.092 for insulin level and −0.084 for HOMA-IR, P = 0.0019 and P = 0.0041, respectively, and r coefficient for FEV1/FVC ratio = −0.061 for insulin level −0.081 and for HOMA-IR, P = 0.0269 and P = 0.0026, respectively). This evidence concerns the gene INS and asthma.