The TGF-Beta signaling hallmark gene set was significantly enriched (p = 6e-3, FDR q = 2.7e-2) with genes having high risk scores including RHOA, TGFB1, TGFBR1, SERPINE1, JUNB1 and ARID4B. The Epithelial to Mesenchymal Transition gene set was also significantly enriched (p = 1.6e-1, FDR q = 1.55e-1) with genes having high risk scores including MMP1/2/3, IL6, ECM1, and VCAM1. TGF-Beta signaling is understood to be one of the main pathways involved in EMT, and our results support the importance of EMT in determining glioma patient outcomes. The gene discussed is MMP1; the disease is central nervous system cancer.