The top-ranked feature associated with poor prognosis in our analysis was deletion of CDKN2A which is strongly associated with the aggressive astrocytomas, as well as with a subset of poor prognosis IDH-mutant astrocytomas that lack broad DNA hypermethylation (GCIMP-low)33. The gene discussed is CDKN2A; the disease is astrocytoma (excluding glioblastoma).