CD4 and cardiovascular disorder: It has been demonstrated that circulating anti-CMV IgG antibodies and CMV-specific T-cell responses are associated with cardiovascular diseases and physical function impairment23,25,26,43, suggesting that in HIV+ individuals with poor CD4+ T-cell recovery the high CMV-specific response, probably due to episodes of CMV reactivation mainly in the genital tract41,44, may have an impact in the higher mortality and morbidity observed in those individuals.