OPA1 and autosomal dominant optic atrophy: Widespread reductions in FA (including the external capsule and cerebral peduncles) were found in three different clinical studies; in a group of pediatric patients, identified as having complex I or complex I/III deficits, among patients with m.3243A > G mutation and patients with OPA1 autosomal dominant optic atrophy and Leber’s hereditary optic neuropathy61–63.