TNFSF10 and hematopoietic and lymphoid cell neoplasm: As shown in Fig. 4e and f, the TRAIL promoter region in MCF7 and MDA-MB231 cells (as well as in hematological cancer cells, such as U937 and NB4 cells, data not shown) is mainly hyperacetylated, but also trimethylated, in a time-dependent manner upon 3 and 24 hours of treatment with 5 μM MS-275.