CYGB is ubiquitouslyexpressed in all organs other than the human liver, where it is expressed solely inHSCs, and its expression is reduced in the livers of patients with CLD (20, 21).Recently, our laboratory and others have reported that CYGB plays a protective role bothin neuronal cells and in the liver by reducing reactive oxygen species (ROS) (22, 23).Furthermore, the administration of human recombinant CYGB was reported to attenuatethioacetamide-induced liver fibrosis in a rat model (24). Here, CYGB is linked to Hepatic fibrosis.