BCL2 and cystic fibrosis: Inflammation has been suggested to prolong neutrophil lifespan by inducing changes in the expression of Bcl-2 family members, in particular Mcl-123 and BAX.5 Using samples from patients with CF, we demonstrated no difference in the expression of Mcl-1 and BAX between CF neutrophils and healthy controls (figure 3A–C), suggesting that inflammation-induced dysregulation of intrinsic apoptosis-regulating proteins was not the cause of the prolonged survival of CF neutrophils.