Armc8 is also a key component of the CTLH (C-terminal to lissencephaly type-1-like homology motif) complex of mammalian cells, which has been characterized as an FBPase (fructose-1, 6-bisphosphatase)-degrading complex (Zhao et al. 2016). Here, ARMC8 is linked to classic lissencephaly.