Interestingly, among the proteins overrepresented in protein aggregates of three MFM types (myotilinopathy, desminopathy and filaminopathy), there were many sarcomeric and other cytoskeletal proteins, especially Z-disc proteins, as well as various heat shock proteins (including HSP27 and αB-crystallin), but not titin [28, 40, 41]. This evidence concerns the gene DNM2 and myofibrillar myopathy 5.