CAV1 and neoplasm: Moreover, apart from oxidative stress, there are other possible mechanisms that may participate in deregulation of Cav-1 in CAFs, such as activation of TGF-beta signaling pathway, inactivation of tumor suppress genes (such as p53) and activation of oncogenes (H-ras, v-abl, brc-abl, TGF etc.)[64, 65].