In the theory of ‘the autophagic tumor stroma model of cancer metabolism’, cancer cells secrete ROS in microenvironment, which induces oxidative stress in CAFs, and then leads to the onset of autophagy and production of auto-phagosomes that fuse with lysosomes, resulting in degradation of mitochondria and Caveolin-1 (Cav-1). This evidence concerns the gene CAV1 and neoplasm.