We have discussed loss of Cav-1 is one of significant reasons which is responsible for aerobic glycolysis in CAFs, correspondingly, it has been shown that combination of two potent mitochondrial ‘poisons’ (metformin and arsenic trioxide (ATO)) are able to re-sensitize breast cancer cells that are CAF-induced tamoxifen and fulvestrant resistance [107]. Here, CAV1 is linked to breast cancer.