In human NSCLC xenograft models RT leads to a chronic sustained expression and activation of the entire ATM-AMPK-p53/p21cip1 pathway but inhibition of mTOR signals [84] that is associated with inhibition of tumor growth, expression of apoptosis markers and inhibition of angiogenesis [84]. The gene discussed is CDKN1A; the disease is non-small cell lung carcinoma.