EGFR and non-small cell lung carcinoma: Three studies examine metformin in stage III-IV NSCLC in combination with chemotherapy: one in combination with carbohydrate restriction (NCT02254512), a second with anti-EGFR (Gefitinib: NCT01997775) and a third with anti-angiogenic (Bevacizumab: NCT01578551) targeted therapy, having disease control (PFS) or biomarker (IL6) outcomes.