However, miR-155 a typical multifunctional microRNA which in atherosclerosis(AS) also acts as an anti-inflammatory microRNA [57], is evidenced by hematopoietic deficiency of miR155 enhances the ‘inflammatory’ monocyte subset (CD11b+Ly6G−Ly6Chi) and inhibits ‘resident’ monocytes (CD11b+Ly6G−Ly6Clow) in the circulation [58]These results might be explained by the appropriate activation of miR-155 is used to hold the balance between M1 and M2 macrophages in the disease pathogensis. Here, ITGAM is linked to atherosclerosis.