The Cancer Genome Atlas Group identified four major molecular subtypes [6]: i) the most frequent (around 50% of tumors) is characterized by chromosomal instability (CIN) and amplification of genes, mainly encoding tyrosine kinase receptors; ii) tumors with Microsatellite Instability (MSI, 22%), presenting a very high mutation rate and DNA methylation; iii) genomically stable (20%) tumors and iv) Epstein Barr Virus positive tumors (9%), characterized by DNA hypermethylation, high frequency of PIK3CA mutations and PDL1/PDL2 overexpression. Here, CD274 is linked to cancer.