The growth inhibition of adiponectin in cancer cells was shown to be mediated through activation of AMPK, inhibition of PI3K/Akt and ERK1/2 pathways, down-regulation of leptin-induced STAT3 phosphorylation, inhibition of NF-κB and Wnt/β-catenin pathways, and decrease of ROS production [79]. This evidence concerns the gene AKT1 and cancer.