In correlation with other previous observations made in vivo showing that low doses of curcumin downregulated the Bax level while augmenting Bcl-2 expression in CD4+/CD8+ T cells, thereby protecting the cells from tumor-induced apoptosis [67], our results also agree with the attenuation of tumor-induced suppression of cell-mediated immune responses described by Bhattacharyya and colleagues [68]. Here, CD4 is linked to neoplasm.