Finally, in contrast with previous reports mentioning the presence of CD8+ macrophages in the context of glioma or various other CNS pathologies [69], our observations, including HPS staining and immunohistochemical labeling with anti-CD8 and anti-ED1, show that both the distribution and the morphology of these clusters of CD8+ cells differ from those of monocytes/macrophages. This evidence concerns the gene EDA and central nervous system cancer.