The predictive role of EGFR gene copy number as determined by fluorescence in situ hybridization (FISH) is a matter of controversy.[3, 20–22] As high percentages of EGFR mutant NSCLC also demonstrate amplification of the gene, it was postulated that the predictiveness of EGFR high gene copy number could be accounted by the presence of mutation. This evidence concerns the gene EGFR and non-small cell lung carcinoma.