ENPP2 and cancer: It has been reported that the 8q24 region contains multiple enhancer elements which can activate transcription of the nearby oncogene MYC; 8q24 also contains several other genes that functionally participate in cancer development, including ectonucleotide pyrophosphatase/phosphodiesterase 2 gene (ENPP2) and nephroblastoma overexpressed gene (NOV).