In addition, according to the meta-analysis comparing the OS/intracranial PFS/extracranial PFS between WBRT plus EGFR-TKIs and WBRT alone, we noticed that WBRT plus EGFR-TKIs is associated with significantly better OS, intracranial PFS and extracranial PFS in NSCLC patients with multiple BM. Here, EGFR is linked to non-small cell lung carcinoma.