For the association of APLNR gene rs9943582 polymorphism with CAD risk, the mutant T allele was associated with a 5.2% increased risk relative to the wild C allele (OR: 1.052, 95% CI: 0.990 to 1.117, P = 0.100) (Figure 1: the LOWER panel), and there was no observable heterogeneity (I2: 0.0%, P = 0.556) and a low probability of publication bias (Figure 2C and 2D) (P for Begg's test: 0.721 and P for Egger's test: 0.953). Here, APLNR is linked to coronary artery disorder.