As shown in Figure 2, patients with increased Cbl-b expression, increased CA19-9 level, lymph node metastasis, or poor tumor differentiation had shorter OS and that the OS in sub-group of serum CA19-9 ≥37 U/mL was significantly associated with Cbl-b expression (Figure 3). This evidence concerns the gene CBLB and metastatic malignant neoplasm in the lymph nodes.