The 2016 CNS WHO criteria state that, for a complete diagnosis of the types of adult glioma, analysis for specific mutations of the two genes, IDH1 and IDH2 (IDH), which encode isocitrate dehydrogenase 1 and 2, respectively, and of chromosome 1p/19q codeletion status, is essential. This evidence concerns the gene IDH2 and central nervous system cancer.