Indeed, all ODGs were positive for both IDH and TERT mutations, seven out of eight ACs were IDH-mutant (cases n.18–24), and no AC samples had mutations in TERT. Finally, the IDH1 R132H mutation was found in only one out of 26 GBM samples (case n 32); conversely, the TERT mutations, which are frequent in GBM, were highly represented in our cases (22 out of 26 GBMs) (Figure 3). Here, IDH2 is linked to glioblastoma.