NOTCH3 and ACTH-producing pituitary gland adenoma: To evaluate Notch protein expression, distribution and cellular localization in human pituitary adenomas (see Table 2) we performed NOTCH3 immunohistochemistry and found that non functioning adenomas, prolactinomas, somatotropinomas and corticotropinomas expressed NOTCH3 protein in the cytoplasm and membrane of tumor cells (Figure 3A–3D).