CDK8 and non-small cell lung carcinoma: Meanwhile, miR-107-5p has also been proved to target other genes, such as over-expression of miR-107 could arrest cell cycle and suppress cell proliferation in H1299 and A549 cells by targeting CDK6, miR-107 could directly target CDK8 to further inhibit cell proliferation in A549 cells and miR-107 could inhibit tumor growth and metastasis in NSCLC cells by directly targeting BDNF and regulating the P13K/AKT signaling pathway indirectly [26, 29, 30] (Figure 7).