Our results demonstrated that EGFR was a direct target of miR-107-5p in NSCLC cell lines for the first time, and based on previous studies in our lab, we found that miR-150 [28], miR-34a and miR-107-5p may have a close correlation with NSCLC development by partly targeting EGFR. Here, EGFR is linked to non-small cell lung carcinoma.