EGFR and non-small cell lung carcinoma: Tyrosine kinase inhibitors specific to EGFR (EGFR TKIs) are used in patients with NSCLC such as Gefitinib, Erlotinib and Osimertinib, however the limitation of this treatment is the EGFR gene-mutation status, drug resistance to EGFR-TKIs presents a major issue [10].