MAPK8 and cancer: In our previous studies, we observed that DET is the active compound in the medicinal plant which was found to significantly suppress mammary tumor growth and lung metastasis of TS/A (ER+) mammary cancer cells in vivo and in vitro, and restrict cancer cell activity through regulating multiple molecular mechanisms, including formation of centrosomal aggregates, deregulation of the ubiquitin-proteasome system and NF-κB activity, induction of ROS/JNK-mediated apoptosis and protein carbonylation, and restriction of cell motility by inhibiting m-calpain enzyme activity [8–10].