In a study of Chinese genetic variants in lipid parameters and dyslipidemia, HDL-C levels decreased from 1.38 mmol/L for individuals carrying three or fewer risk alleles to 1.14 mmol/L for individuals carrying all eight risk alleles (MLXIPL rs17145738, LPLrs326, LIPC rs1800588 and CETP rs3764261) [35]. The gene discussed is MLXIPL; the disease is metabolic syndrome.