Furthermore, We demonstrated that Wip1-shRNA significantly inhibited MMP-2 expression in ICC cells, which was in collaborate with a previous report that knock-down the expression Wip1 can inhibit migration and invasion target VEGF-C and MMP-9 pathway in salivary adenoid cystic carcinoma [41]. This evidence concerns the gene MMP2 and intrahepatic cholangiocarcinoma.