PPM1D and neoplasm: Accumulating studies showed that over expression of Wip1 will disrupt multiple pathways implicated in the regulation of p38MAPK-p53 tumor suppressor responses, which caused down target Wnt-p53 dephosphrylation through limiting the p38MAPK-STAT1 pathway, and promoted tumor formation in humans by decreasing p16/p19 levels [11, 25].