IL-8 siRNA reduced p38 MAPK and ERK gene expressions in three types of HNSCC cell by factors of 0.5 and 0.1 in SCC4, 0.9 and 0.1 in SCC9 and 0.6 and 0.3 in SCC25 cells, respectively. This evidence concerns the gene CXCL8 and head and neck squamous cell carcinoma.