Taken together, our data revealed that, in the presence of Baicalein, NEDD9 overexpression was able to reactivate Akt and ERK and rescue the phenotype involving proliferation, motility and apoptosis of pancreatic cancer cells, indicating that NEDD9 is a primary target of Baicalein in pancreatic cancer cells. Here, NEDD9 is linked to familial pancreatic carcinoma.