Supplementary Table 1 CD138- cells exhibited little sensitivity to signal transduction inhibitors targeting PI3K-AKT-mTOR, MAPK, and IGF1R, HSP90 and BCL2 family members, with responses similar to that observed in BM cells from healthy individuals. In contrast, MM derived CD138+ cells were insensitive to nucleoside analogues including clofarabine, cladribine and gemcitabine, while CD138- cells were sensitive (Figure 1C). This evidence concerns the gene AKT1 and Miyoshi myopathy.