Second-generation EGFR-TKIs (e.g., Afatinib), which irreversibly bind to the tyrosine kinase of EGFR, are used as first-line treatments for advanced NSCLC harboring activating EGFR mutations; however, acquired resistance remains an intractable problem [23, 24]. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.